Thermodynamic study of the solubility of ibuprofen in acetone and dichloromethane

Authors

  • Diana Marcela Aragón Universidad Nacional de Colombia; Departamento de Farmacia; Sección de Farmacotecnia
  • Jaiver Eduardo Rosas Universidad Nacional de Colombia; Departamento de Farmacia; Sección de Farmacotecnia
  • Fleming Martínez Universidad Nacional de Colombia; Departamento de Farmacia; Sección de Farmacotecnia

DOI:

https://doi.org/10.1590/S1984-82502010000200009

Keywords:

Ibuprofen, Solubility, Transfer, Solution thermodynamics, Organic solvents

Abstract

Thermodynamic functions, Gibbs energy, enthalpy and entropy for the solution processes of ibuprofen (IBP) in acetone and dichloromethane (DCM) were calculated from solubility values obtained at temperatures ranging from 293.15 K to 313.15 K. The respective thermodynamic functions for mixing and solvation processes as well as the activity coefficients for the solute were calculated. IBP solubility was high and proved similar in both solvents but was greater in DCM than acetone. In addition, the thermodynamic quantities for the transfer process of this drug from cyclohexane to the organic solvents were also calculated in order to estimate the contributions of hydrogen-bonds or of other dipolar interactions. The results were discussed in terms of solute-solvent interactions.

Downloads

Download data is not yet available.

Downloads

Published

2010-06-01

Issue

Vol. 46 No. 2 (2010)

Section

Original Papers

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on-line journal has open and free access.

How to Cite

Thermodynamic study of the solubility of ibuprofen in acetone and dichloromethane . (2010). Brazilian Journal of Pharmaceutical Sciences, 46(2), 227-235. https://doi.org/10.1590/S1984-82502010000200009