Development of a dissolution test for lamotrigine in tablet form using an ultraviolet method

Authors

  • Magda Targa Martins Universidade Federal do Rio Grande do Sul; Faculdade de Farmácia; Departamento de Farmácia
  • Clésio Soldatelli Paim Universidade Federal do Rio Grande do Sul; Faculdade de Farmácia; Departamento de Farmácia
  • Martin Steppe Universidade Federal do Rio Grande do Sul; Faculdade de Farmácia; Departamento de Farmácia

DOI:

https://doi.org/10.1590/S1984-82502010000200003

Keywords:

Lamotrigine, Dissolution test^i1^svalidat, Medicines^i1^squality cont

Abstract

A dissolution test for tablets containing 100 mg of lamotrigine was developed and validated. The dissolution test was applied to compare the dissolution profile of Neural® with the reference product Lamictal®. The analysis procedure was carried out using a simple ultraviolet method at 267 nm. After the determination of solubility and sink conditions, the parameters selected were paddles at 50 rpm, 900 mL of 0.01 M hydrochloric acid, and 30 minutes duration (single point). This method was validated for specificity, linearity, accuracy, precision and robustness. Lamotrigine stability was also evaluated in dissolution medium.

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Published

2010-06-01

Issue

Vol. 46 No. 2 (2010)

Section

Original Papers

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on-line journal has open and free access.

How to Cite

Development of a dissolution test for lamotrigine in tablet form using an ultraviolet method . (2010). Brazilian Journal of Pharmaceutical Sciences, 46(2), 179-186. https://doi.org/10.1590/S1984-82502010000200003