Stability evaluation of tocopheryl acetate and ascorbyl tetraisopalmitate in isolation and incorporated in cosmetic formulations using thermal analysis

Authors

  • Mariana Mandelli de Almeida University of São Paulo; Faculty of Pharmaceutical Sciences; Pharmacy Department
  • Cibele Rosana Ribeiro de Castro Lima University of São Paulo; Faculty of Pharmaceutical Sciences; Pharmacy Department
  • Joyce Santos Quenca-Guillen University of São Paulo; Faculty of Pharmaceutical Sciences; Pharmacy Department
  • Elder Moscardini Filho Federal University of São Paulo; Faculty of Chemistry; Department of Exact and Earth Sciences
  • Lucildes Pita Mercuri Federal University of São Paulo; Faculty of Chemistry; Department of Exact and Earth Sciences
  • Maria Inês Rocha Miritello Santoro University of São Paulo; Faculty of Pharmaceutical Sciences; Pharmacy Department
  • Erika Rosa Maria Kedor-Hackmann University of São Paulo; Faculty of Pharmaceutical Sciences; Pharmacy Department

DOI:

https://doi.org/10.1590/S1984-82502010000100015

Keywords:

Thermal analysis, Cosmetic emulsion^i1^squalitative analy, Cosmetics^i1^squality cont, Tocopheryl acetate^i1^santioxidant act, Ascorbyl tetraisopalmitate^i1^santioxidant act, Vitamins^i1^suse in cosmet

Abstract

In view of the increase in the number of cosmetic preparations containing antioxidant vitamins, chiefly, due to their action in preventing the process of skin aging, there is a need to develop pre-formulation studies and to validate analytical methods in order to obtain high quality products. Thus, the objective of this research was to evaluate and compare the thermal behavior of tocopheryl acetate and ascorbyl tetraisopalmitate as raw materials, and incorporated into a base cream. Thermogravimetry (TG / DTG) and differential scanning calorimetry (DSC) were used for this purpose. Both vitamins were found to be stable up to 250ºC. The base cream (placebo) and the sample (base cream containing the vitamins) presented different weight loss. Thermal analysis has shown itself to be an excellent tool for the characterization of these vitamins and can be used in routine analysis for quality control of this type of cosmetic formulation.

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Published

2010-03-01

Issue

Vol. 46 No. 1 (2010)

Section

Original Papers

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on-line journal has open and free access.

How to Cite

Stability evaluation of tocopheryl acetate and ascorbyl tetraisopalmitate in isolation and incorporated in cosmetic formulations using thermal analysis . (2010). Brazilian Journal of Pharmaceutical Sciences, 46(1), 129-134. https://doi.org/10.1590/S1984-82502010000100015