Mucoadhesive drug delivery systems

Authors

  • Flávia Chiva Carvalho São Paulo State University; School of Pharmaceutical Sciences
  • Marcos Luciano Bruschi State University of Maringá; Department of Pharmacy
  • Raul Cesar Evangelista São Paulo State University; School of Pharmaceutical Sciences,; Department of Drugs and Pharmaceuticals
  • Maria Palmira Daflon Gremião São Paulo State University; School of Pharmaceutical Sciences,; Department of Drugs and Pharmaceuticals

DOI:

https://doi.org/10.1590/S1984-82502010000100002

Keywords:

Mucoadhesion, Bioadhesion, Mucoadhesive systems, Drugs^i1^sdeliv

Abstract

Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion, fracture and mechanical. Several in vitro and in vivo methodologies are proposed for studying its mechanisms. However, mucoadhesion is not yet well understood. The aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery systems.

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Published

2010-03-01

Issue

Vol. 46 No. 1 (2010)

Section

Reviews

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on-line journal has open and free access.

How to Cite

Mucoadhesive drug delivery systems . (2010). Brazilian Journal of Pharmaceutical Sciences, 46(1), 1-17. https://doi.org/10.1590/S1984-82502010000100002