Intraoral lipoma with degenerative changes mimicking atypical lipomatous tumor: an immunohistochemical study

Authors

  • Evânio Vilela Silva Universidade Estadual Paulista (Unesp), Araraquara Dental School, Oral Medicine, Department of Diagnosis and Surgery, Araraquara, SP, Brasil https://orcid.org/0000-0001-9883-9776
  • Heitor Albergoni Silveira Universidade Estadual Paulista (Unesp), Araraquara Dental School, Oral Medicine, Department of Diagnosis and Surgery, Araraquara, SP, Brasil https://orcid.org/0000-0002-6724-3504
  • Beatriz Zamboni Martins Panucci Universidade de São Paulo (USP), Ribeirão Preto Dental School, Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto, SP, Brasil https://orcid.org/0000-0001-8722-7897
  • Kelly Fernanda Molena Universidade de São Paulo (USP), Ribeirão Preto Dental School, Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto, SP, Brasil https://orcid.org/0000-0002-7290-8451
  • Luciana Yamamoto Almeida Universidade Estadual Paulista (Unesp), Araraquara Dental School, Oral Medicine, Department of Diagnosis and Surgery, Araraquara, SP, Brasil https://orcid.org/0000-0001-5403-4052
  • Andreia Bufalino Universidade Estadual Paulista (Unesp), Araraquara Dental School, Oral Medicine, Department of Diagnosis and Surgery, Araraquara, SP, Brasil https://orcid.org/0000-0002-6714-6253
  • Jorge Esquiche León Universidade de São Paulo (USP), Ribeirão Preto Dental School, Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto, SP, Brasil https://orcid.org/0000-0002-9668-5870

DOI:

https://doi.org/10.4322/acr.2023.413

Keywords:

Lipoma, Liposarcoma, Mouth, Immunohistochemistry

Abstract

Lipomas are mesenchymal neoplasms relatively uncommon in the oral cavity. Lipomas can exhibit histopathological features mimicking atypical lipomatous tumors (ALT) or dysplastic lipoma (DL) in the presence of degenerative changes. Relevantly, immunohistochemistry assists in the correct diagnosis. Herein, we present the case of a 54-year-old male with a sessile nodule located on the dorsum of the tongue. The histopathological analysis showed a diffuse, non-circumscribed adipocytic proliferation constituted by cells of variable size containing cytoplasmic vacuoles and displaced nuclei, some resembling lipoblasts supported by fibrous connective tissue stroma. By immunohistochemistry, tumor cells were positive for vimentin, S100, FASN, CD10, and p16. Rb expression was intact. Moreover, CD34, p53, MDM2, and CDK4 were negative. After 2-year of follow-up, no alteration or recurrence was observed. In conclusion, MDM2, CDK4, p53, and Rb immunomarkers can be used reliably to differentiate benign lipoma with degenerative changes from ALT and DL.

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Published

2022-12-22

Issue

Vol. 13 (2023)

Section

Clinical Case Report

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How to Cite

Evânio Vilela Silva, Heitor Albergoni Silveira, Beatriz Zamboni Martins Panucci, Kelly Fernanda Molena, Luciana Yamamoto Almeida, Andreia Bufalino, & Jorge Esquiche León. (2022). Intraoral lipoma with degenerative changes mimicking atypical lipomatous tumor: an immunohistochemical study. Autopsy and Case Reports, 13, e2021413. https://doi.org/10.4322/acr.2023.413