Synthesis and evaluation of platinum complexes with potential antitumor activity

Authors

  • Rachel Lima Marcelino Freire Universidade Federal de Minas Gerais; Faculdade de Farmácia; Departamento de Produtos Farmacêuticos
  • Maria Betânia de Freitas Marques Universidade Federal de Minas Gerais; Faculdade de Farmácia; Departamento de Produtos Farmacêuticos
  • Elaine Maria de Souza-Fagundes Universidade Federal de Minas Gerais; Instituto de Ciências Biológicas; Departamento de Fisiologia e Biofísica
  • Renata Barbosa de Oliveira Universidade Federal de Minas Gerais; Faculdade de Farmácia; Departamento de Produtos Farmacêuticos
  • Ricardo José Alves Universidade Federal de Minas Gerais; Faculdade de Farmácia; Departamento de Produtos Farmacêuticos

DOI:

https://doi.org/10.1590/s2175-97902017000115235

Keywords:

/Cytotoxic activity, Platinum complexes/ Ehrlich solid tumor activity.

Abstract

A novel series of platinum (II) complexes was synthesized and the complexes were evaluated for their in vitro cytotoxicity against four human cancer cells lines. Five platinum complexes showed activity against at least one tumor cell line. Complexes 3 and 6 were promising, being active, at micromolar concentrations, against all the assayed tumor cell lines. Compound 3 was selected for further studies in mice with Ehrlich solid tumors and it was able to reduce the rate of tumor growth significantly during the first seven days. However, at the end of the experiments, there was no significant difference between the group of animals treated with 3 and the control group. The low solubility of the compound in the assay conditions can explain, at least in part, these results.

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Published

2017-01-01

Issue

Section

Articles

How to Cite

Synthesis and evaluation of platinum complexes with potential antitumor activity. (2017). Brazilian Journal of Pharmaceutical Sciences, 53(1), e15235-. https://doi.org/10.1590/s2175-97902017000115235